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A 37-year-old female with Graves’ disease who requires antithyroid therapy becomes pregnant. Which antithyroid drug is safest?

  1. Potassium iodide (KI)

  2. Methimazole

  3. PTU

  4. Potassium perchlorate (KClO4)



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7-43. The answer is c. (Hardman, p 1401.)
Propylthiouracil is more strongly protein bound and crosses the placenta to a lesser degree than methimazole and is, therefore, the safest antithyroid drug in pregnancy.