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A 45-year-old female treated for ovarian cancer develops difficulty hearing. Which of the following agents most likely caused these findings?

a. Paclitaxel
b. Doxorubicin
c. Bleomycin
d. 5-FU
e. Cisplatin

 

in Otolaryngology by

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The answer is e. (Hardman, pp 1269–1271.) Cisplatin causes acoustic nerve damage. Paclitaxel causes peripheral neuritis. Dose- dependent pneumonitis and fibrosis are caused by bleomycin. Doxorubicin causes cardiac toxicity, which may lead to congestive heart failure. 5-Fluorouracil causes myelosuppression, stomatitis, and oral and gastrointestinal ulcerations.
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