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Which drug cause hypertensive crises when used with tyramine:


b) Tricyclic antidepressant

c) mono-amine oxidase inhibitors

d) Benzodiazepines
in Pharmacology by

2 Answers

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c) mono-amine oxidase inhibitors
Tyramine is an amino acid that acts as an indirect sympathomimetic and is able to trigger a serious hypertensive reaction in patients being treated with MAO inhibitors. These agents inhibit monoamine oxidase, an enzyme found in the gastrointestinal tract and which has precisely the function of counteracting the tyramine.
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Mono amine oxidase inhibitor