Avoid proteinuria has been newly added target. This is achieved by lowering blood pressure and RAAS blockade, effects achieved as already cited with these drugs. In the glomeruli of diabetic patients increases the pressure and, furthermore, the podocytes are dysfunctional and, regulating the passage of the filtrate proteins begin to accumulate in the basal membrane and this promotes fibrosis. By using the efferent arteriole ACEI and low pressure dilates glomerulus and also to block the RAAS antifibrotic effect is markedly. The RAAS blockade has proven effective on vascular protection and restoration of endothelial function.